An RLP23-SOBIR1-BAK1 complex mediates NLP-triggered immunity.
Identifieur interne : 000F30 ( Main/Exploration ); précédent : 000F29; suivant : 000F31An RLP23-SOBIR1-BAK1 complex mediates NLP-triggered immunity.
Auteurs : Isabell Albert [Allemagne] ; Hannah Böhm [Allemagne] ; Markus Albert [Allemagne] ; Christina E. Feiler [Allemagne] ; Julia Imkampe [Allemagne] ; Niklas Wallmeroth [Allemagne] ; Caterina Brancato [Allemagne] ; Tom M. Raaymakers [Pays-Bas] ; Stan Oome [Pays-Bas] ; Heqiao Zhang [République populaire de Chine] ; Elzbieta Krol [Allemagne] ; Christopher Grefen [Allemagne] ; Andrea A. Gust [Allemagne] ; Jijie Chai [République populaire de Chine] ; Rainer Hedrich [Allemagne] ; Guido Van Den Ackerveken [Pays-Bas] ; Thorsten Nürnberger [Allemagne]Source :
- Nature plants [ 2055-0278 ] ; 2015.
Abstract
Plants and animals employ innate immune systems to cope with microbial infection. Pattern-triggered immunity relies on the recognition of microbe-derived patterns by pattern recognition receptors (PRRs). Necrosis and ethylene-inducing peptide 1-like proteins (NLPs) constitute plant immunogenic patterns that are unique, as these proteins are produced by multiple prokaryotic (bacterial) and eukaryotic (fungal, oomycete) species. Here we show that the leucine-rich repeat receptor protein (LRR-RP) RLP23 binds in vivo to a conserved 20-amino-acid fragment found in most NLPs (nlp20), thereby mediating immune activation in Arabidopsis thaliana. RLP23 forms a constitutive, ligand-independent complex with the LRR receptor kinase (LRR-RK) SOBIR1 (Suppressor of Brassinosteroid insensitive 1 (BRI1)-associated kinase (BAK1)-interacting receptor kinase 1), and recruits a second LRR-RK, BAK1, into a tripartite complex upon ligand binding. Stable, ectopic expression of RLP23 in potato (Solanum tuberosum) confers nlp20 pattern recognition and enhanced immunity to destructive oomycete and fungal plant pathogens, such as Phytophthora infestans and Sclerotinia sclerotiorum. PRRs that recognize widespread microbial patterns might be particularly suited for engineering immunity in crop plants.
DOI: 10.1038/nplants.2015.140
PubMed: 27251392
Affiliations:
- Allemagne, Pays-Bas, République populaire de Chine
- Bade-Wurtemberg, Bavière, District de Basse-Franconie, District de Tübingen, Utrecht (province)
- Pékin, Tübingen, Utrecht, Wurtzbourg
- Université d'Utrecht
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Gust</name><affiliation wicri:level="3"><nlm:affiliation>Center of Plant Molecular Biology (ZMBP), University of Tübingen, Auf der Morgenstelle 32, Tübingen D-72076, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center of Plant Molecular Biology (ZMBP), University of Tübingen, Auf der Morgenstelle 32, Tübingen D-72076</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Chai, Jijie" sort="Chai, Jijie" uniqKey="Chai J" first="Jijie" last="Chai">Jijie Chai</name><affiliation wicri:level="1"><nlm:affiliation>Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Hedrich, Rainer" sort="Hedrich, Rainer" uniqKey="Hedrich R" first="Rainer" last="Hedrich">Rainer Hedrich</name><affiliation wicri:level="3"><nlm:affiliation>Department of Plant Physiology and Biophysics, University of Würzburg, Julius-von-Sachs-Platz 2, Würzburg D-97082, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Plant Physiology and Biophysics, University of Würzburg, Julius-von-Sachs-Platz 2, Würzburg D-97082</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Van Den Ackerveken, Guido" sort="Van Den Ackerveken, Guido" uniqKey="Van Den Ackerveken G" first="Guido" last="Van Den Ackerveken">Guido Van Den Ackerveken</name><affiliation wicri:level="4"><nlm:affiliation>Plant-Microbe Interactions, Department of Biology, Utrecht University, Padualaan 8, Utrecht 3584 CH, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Plant-Microbe Interactions, Department of Biology, Utrecht University, Padualaan 8, Utrecht 3584 CH</wicri:regionArea><orgName type="university">Université d'Utrecht</orgName><placeName><settlement type="city">Utrecht</settlement><region nuts="2">Utrecht (province)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Centre for BioSystems Genomics (CBSG), Wageningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Centre for BioSystems Genomics (CBSG), Wageningen</wicri:regionArea><wicri:noRegion>Wageningen</wicri:noRegion></affiliation></author><author><name sortKey="Nurnberger, Thorsten" sort="Nurnberger, Thorsten" uniqKey="Nurnberger T" first="Thorsten" last="Nürnberger">Thorsten Nürnberger</name><affiliation wicri:level="3"><nlm:affiliation>Center of Plant Molecular Biology (ZMBP), University of Tübingen, Auf der Morgenstelle 32, Tübingen D-72076, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center of Plant Molecular Biology (ZMBP), University of Tübingen, Auf der Morgenstelle 32, Tübingen D-72076</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:27251392</idno><idno type="pmid">27251392</idno><idno type="doi">10.1038/nplants.2015.140</idno><idno type="wicri:Area/Main/Corpus">000F11</idno><idno type="wicri:explorRef" wicri:stream="Main" 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Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Bohm, Hannah" sort="Bohm, Hannah" uniqKey="Bohm H" first="Hannah" last="Böhm">Hannah Böhm</name><affiliation wicri:level="3"><nlm:affiliation>Center of Plant Molecular Biology (ZMBP), University of Tübingen, Auf der Morgenstelle 32, Tübingen D-72076, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center of Plant Molecular Biology (ZMBP), University of Tübingen, Auf der Morgenstelle 32, Tübingen D-72076</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Albert, Markus" sort="Albert, Markus" uniqKey="Albert M" first="Markus" last="Albert">Markus Albert</name><affiliation wicri:level="3"><nlm:affiliation>Center of Plant Molecular Biology (ZMBP), University of Tübingen, Auf der Morgenstelle 32, Tübingen D-72076, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center of Plant Molecular Biology (ZMBP), University of Tübingen, Auf der Morgenstelle 32, Tübingen D-72076</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Feiler, Christina E" sort="Feiler, Christina E" uniqKey="Feiler C" first="Christina E" last="Feiler">Christina E. Feiler</name><affiliation wicri:level="3"><nlm:affiliation>Center of Plant Molecular Biology (ZMBP), University of Tübingen, Auf der Morgenstelle 32, Tübingen D-72076, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center of Plant Molecular Biology (ZMBP), University of Tübingen, Auf der Morgenstelle 32, Tübingen D-72076</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Imkampe, Julia" sort="Imkampe, Julia" uniqKey="Imkampe J" first="Julia" last="Imkampe">Julia Imkampe</name><affiliation wicri:level="3"><nlm:affiliation>Center of Plant Molecular Biology (ZMBP), University of Tübingen, Auf der Morgenstelle 32, Tübingen D-72076, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center of Plant Molecular Biology (ZMBP), University of Tübingen, Auf der Morgenstelle 32, Tübingen D-72076</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Wallmeroth, Niklas" sort="Wallmeroth, Niklas" uniqKey="Wallmeroth N" first="Niklas" last="Wallmeroth">Niklas Wallmeroth</name><affiliation wicri:level="3"><nlm:affiliation>Center of Plant Molecular Biology (ZMBP), University of Tübingen, Auf der Morgenstelle 32, Tübingen D-72076, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center of Plant Molecular Biology (ZMBP), University of Tübingen, Auf der Morgenstelle 32, Tübingen D-72076</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Brancato, Caterina" sort="Brancato, Caterina" uniqKey="Brancato C" first="Caterina" last="Brancato">Caterina Brancato</name><affiliation wicri:level="3"><nlm:affiliation>Center of Plant Molecular Biology (ZMBP), University of Tübingen, Auf der Morgenstelle 32, Tübingen D-72076, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center of Plant Molecular Biology (ZMBP), University of Tübingen, Auf der Morgenstelle 32, Tübingen D-72076</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Raaymakers, Tom M" sort="Raaymakers, Tom M" uniqKey="Raaymakers T" first="Tom M" last="Raaymakers">Tom M. Raaymakers</name><affiliation wicri:level="4"><nlm:affiliation>Plant-Microbe Interactions, Department of Biology, Utrecht University, Padualaan 8, Utrecht 3584 CH, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Plant-Microbe Interactions, Department of Biology, Utrecht University, Padualaan 8, Utrecht 3584 CH</wicri:regionArea><orgName type="university">Université d'Utrecht</orgName><placeName><settlement type="city">Utrecht</settlement><region nuts="2">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Oome, Stan" sort="Oome, Stan" uniqKey="Oome S" first="Stan" last="Oome">Stan Oome</name><affiliation wicri:level="4"><nlm:affiliation>Plant-Microbe Interactions, Department of Biology, Utrecht University, Padualaan 8, Utrecht 3584 CH, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Plant-Microbe Interactions, Department of Biology, Utrecht University, Padualaan 8, Utrecht 3584 CH</wicri:regionArea><orgName type="university">Université d'Utrecht</orgName><placeName><settlement type="city">Utrecht</settlement><region nuts="2">Utrecht (province)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Centre for BioSystems Genomics (CBSG), Wageningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Centre for BioSystems Genomics (CBSG), Wageningen</wicri:regionArea><wicri:noRegion>Wageningen</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Heqiao" sort="Zhang, Heqiao" uniqKey="Zhang H" first="Heqiao" last="Zhang">Heqiao Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Krol, Elzbieta" sort="Krol, Elzbieta" uniqKey="Krol E" first="Elzbieta" last="Krol">Elzbieta Krol</name><affiliation wicri:level="3"><nlm:affiliation>Department of Plant Physiology and Biophysics, University of Würzburg, Julius-von-Sachs-Platz 2, Würzburg D-97082, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Plant Physiology and Biophysics, University of Würzburg, Julius-von-Sachs-Platz 2, Würzburg D-97082</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Grefen, Christopher" sort="Grefen, Christopher" uniqKey="Grefen C" first="Christopher" last="Grefen">Christopher Grefen</name><affiliation wicri:level="3"><nlm:affiliation>Center of Plant Molecular Biology (ZMBP), University of Tübingen, Auf der Morgenstelle 32, Tübingen D-72076, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center of Plant Molecular Biology (ZMBP), University of Tübingen, Auf der Morgenstelle 32, Tübingen D-72076</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Gust, Andrea A" sort="Gust, Andrea A" uniqKey="Gust A" first="Andrea A" last="Gust">Andrea A. Gust</name><affiliation wicri:level="3"><nlm:affiliation>Center of Plant Molecular Biology (ZMBP), University of Tübingen, Auf der Morgenstelle 32, Tübingen D-72076, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center of Plant Molecular Biology (ZMBP), University of Tübingen, Auf der Morgenstelle 32, Tübingen D-72076</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Chai, Jijie" sort="Chai, Jijie" uniqKey="Chai J" first="Jijie" last="Chai">Jijie Chai</name><affiliation wicri:level="1"><nlm:affiliation>Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Hedrich, Rainer" sort="Hedrich, Rainer" uniqKey="Hedrich R" first="Rainer" last="Hedrich">Rainer Hedrich</name><affiliation wicri:level="3"><nlm:affiliation>Department of Plant Physiology and Biophysics, University of Würzburg, Julius-von-Sachs-Platz 2, Würzburg D-97082, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Plant Physiology and Biophysics, University of Würzburg, Julius-von-Sachs-Platz 2, Würzburg D-97082</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Van Den Ackerveken, Guido" sort="Van Den Ackerveken, Guido" uniqKey="Van Den Ackerveken G" first="Guido" last="Van Den Ackerveken">Guido Van Den Ackerveken</name><affiliation wicri:level="4"><nlm:affiliation>Plant-Microbe Interactions, Department of Biology, Utrecht University, Padualaan 8, Utrecht 3584 CH, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Plant-Microbe Interactions, Department of Biology, Utrecht University, Padualaan 8, Utrecht 3584 CH</wicri:regionArea><orgName type="university">Université d'Utrecht</orgName><placeName><settlement type="city">Utrecht</settlement><region nuts="2">Utrecht (province)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Centre for BioSystems Genomics (CBSG), Wageningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Centre for BioSystems Genomics (CBSG), Wageningen</wicri:regionArea><wicri:noRegion>Wageningen</wicri:noRegion></affiliation></author><author><name sortKey="Nurnberger, Thorsten" sort="Nurnberger, Thorsten" uniqKey="Nurnberger T" first="Thorsten" last="Nürnberger">Thorsten Nürnberger</name><affiliation wicri:level="3"><nlm:affiliation>Center of Plant Molecular Biology (ZMBP), University of Tübingen, Auf der Morgenstelle 32, Tübingen D-72076, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center of Plant Molecular Biology (ZMBP), University of Tübingen, Auf der Morgenstelle 32, Tübingen D-72076</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author></analytic><series><title level="j">Nature plants</title><idno type="eISSN">2055-0278</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Plants and animals employ innate immune systems to cope with microbial infection. Pattern-triggered immunity relies on the recognition of microbe-derived patterns by pattern recognition receptors (PRRs). Necrosis and ethylene-inducing peptide 1-like proteins (NLPs) constitute plant immunogenic patterns that are unique, as these proteins are produced by multiple prokaryotic (bacterial) and eukaryotic (fungal, oomycete) species. Here we show that the leucine-rich repeat receptor protein (LRR-RP) RLP23 binds in vivo to a conserved 20-amino-acid fragment found in most NLPs (nlp20), thereby mediating immune activation in Arabidopsis thaliana. RLP23 forms a constitutive, ligand-independent complex with the LRR receptor kinase (LRR-RK) SOBIR1 (Suppressor of Brassinosteroid insensitive 1 (BRI1)-associated kinase (BAK1)-interacting receptor kinase 1), and recruits a second LRR-RK, BAK1, into a tripartite complex upon ligand binding. Stable, ectopic expression of RLP23 in potato (Solanum tuberosum) confers nlp20 pattern recognition and enhanced immunity to destructive oomycete and fungal plant pathogens, such as Phytophthora infestans and Sclerotinia sclerotiorum. PRRs that recognize widespread microbial patterns might be particularly suited for engineering immunity in crop plants. </div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">27251392</PMID><DateCompleted><Year>2016</Year><Month>06</Month><Day>03</Day></DateCompleted><DateRevised><Year>2016</Year><Month>06</Month><Day>02</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2055-0278</ISSN><JournalIssue CitedMedium="Internet"><Volume>1</Volume><PubDate><Year>2015</Year><Month>Oct</Month><Day>05</Day></PubDate></JournalIssue><Title>Nature plants</Title><ISOAbbreviation>Nat Plants</ISOAbbreviation></Journal><ArticleTitle>An RLP23-SOBIR1-BAK1 complex mediates NLP-triggered immunity.</ArticleTitle><Pagination><MedlinePgn>15140</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/nplants.2015.140</ELocationID><Abstract><AbstractText>Plants and animals employ innate immune systems to cope with microbial infection. Pattern-triggered immunity relies on the recognition of microbe-derived patterns by pattern recognition receptors (PRRs). Necrosis and ethylene-inducing peptide 1-like proteins (NLPs) constitute plant immunogenic patterns that are unique, as these proteins are produced by multiple prokaryotic (bacterial) and eukaryotic (fungal, oomycete) species. Here we show that the leucine-rich repeat receptor protein (LRR-RP) RLP23 binds in vivo to a conserved 20-amino-acid fragment found in most NLPs (nlp20), thereby mediating immune activation in Arabidopsis thaliana. RLP23 forms a constitutive, ligand-independent complex with the LRR receptor kinase (LRR-RK) SOBIR1 (Suppressor of Brassinosteroid insensitive 1 (BRI1)-associated kinase (BAK1)-interacting receptor kinase 1), and recruits a second LRR-RK, BAK1, into a tripartite complex upon ligand binding. Stable, ectopic expression of RLP23 in potato (Solanum tuberosum) confers nlp20 pattern recognition and enhanced immunity to destructive oomycete and fungal plant pathogens, such as Phytophthora infestans and Sclerotinia sclerotiorum. PRRs that recognize widespread microbial patterns might be particularly suited for engineering immunity in crop plants. </AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Albert</LastName><ForeName>Isabell</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Center of Plant Molecular Biology (ZMBP), University of Tübingen, Auf der Morgenstelle 32, Tübingen D-72076, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Böhm</LastName><ForeName>Hannah</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Center of Plant Molecular Biology (ZMBP), University of Tübingen, Auf der Morgenstelle 32, Tübingen D-72076, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Albert</LastName><ForeName>Markus</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Center of Plant Molecular Biology (ZMBP), University of Tübingen, Auf der Morgenstelle 32, Tübingen D-72076, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Feiler</LastName><ForeName>Christina E</ForeName><Initials>CE</Initials><AffiliationInfo><Affiliation>Center of Plant Molecular Biology (ZMBP), University of Tübingen, Auf der Morgenstelle 32, Tübingen D-72076, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Imkampe</LastName><ForeName>Julia</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Center of Plant Molecular Biology (ZMBP), University of Tübingen, Auf der Morgenstelle 32, Tübingen D-72076, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wallmeroth</LastName><ForeName>Niklas</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Center of Plant Molecular Biology (ZMBP), University of Tübingen, Auf der Morgenstelle 32, Tübingen D-72076, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brancato</LastName><ForeName>Caterina</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Center of Plant Molecular Biology (ZMBP), University of Tübingen, Auf der Morgenstelle 32, Tübingen D-72076, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Raaymakers</LastName><ForeName>Tom M</ForeName><Initials>TM</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-1056-7177</Identifier><AffiliationInfo><Affiliation>Plant-Microbe Interactions, Department of Biology, Utrecht University, Padualaan 8, Utrecht 3584 CH, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Oome</LastName><ForeName>Stan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Plant-Microbe Interactions, Department of Biology, Utrecht University, Padualaan 8, Utrecht 3584 CH, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for BioSystems Genomics (CBSG), Wageningen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Heqiao</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Krol</LastName><ForeName>Elzbieta</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Plant Physiology and Biophysics, University of Würzburg, Julius-von-Sachs-Platz 2, Würzburg D-97082, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grefen</LastName><ForeName>Christopher</ForeName><Initials>C</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-5820-4466</Identifier><AffiliationInfo><Affiliation>Center of Plant Molecular Biology (ZMBP), University of Tübingen, Auf der Morgenstelle 32, Tübingen D-72076, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gust</LastName><ForeName>Andrea A</ForeName><Initials>AA</Initials><AffiliationInfo><Affiliation>Center of Plant Molecular Biology (ZMBP), University of Tübingen, Auf der Morgenstelle 32, Tübingen D-72076, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chai</LastName><ForeName>Jijie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hedrich</LastName><ForeName>Rainer</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Plant Physiology and Biophysics, University of Würzburg, Julius-von-Sachs-Platz 2, Würzburg D-97082, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Van den Ackerveken</LastName><ForeName>Guido</ForeName><Initials>G</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-0183-8978</Identifier><AffiliationInfo><Affiliation>Plant-Microbe Interactions, Department of Biology, Utrecht University, Padualaan 8, Utrecht 3584 CH, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for BioSystems Genomics (CBSG), Wageningen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nürnberger</LastName><ForeName>Thorsten</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Center of Plant Molecular Biology (ZMBP), University of Tübingen, Auf der Morgenstelle 32, Tübingen D-72076, Germany.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>10</Month><Day>05</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Nat Plants</MedlineTA><NlmUniqueID>101651677</NlmUniqueID><ISSNLinking>2055-0278</ISSNLinking></MedlineJournalInfo></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>03</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>08</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>6</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27251392</ArticleId><ArticleId IdType="pii">nplants2015140</ArticleId><ArticleId IdType="doi">10.1038/nplants.2015.140</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>Pays-Bas</li><li>République populaire de Chine</li></country><region><li>Bade-Wurtemberg</li><li>Bavière</li><li>District de Basse-Franconie</li><li>District de Tübingen</li><li>Utrecht (province)</li></region><settlement><li>Pékin</li><li>Tübingen</li><li>Utrecht</li><li>Wurtzbourg</li></settlement><orgName><li>Université d'Utrecht</li></orgName></list><tree><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Albert, Isabell" sort="Albert, Isabell" uniqKey="Albert I" first="Isabell" last="Albert">Isabell Albert</name></region><name sortKey="Albert, Markus" sort="Albert, Markus" uniqKey="Albert M" first="Markus" last="Albert">Markus Albert</name><name sortKey="Bohm, Hannah" sort="Bohm, Hannah" uniqKey="Bohm H" first="Hannah" last="Böhm">Hannah Böhm</name><name sortKey="Brancato, Caterina" sort="Brancato, Caterina" uniqKey="Brancato C" first="Caterina" last="Brancato">Caterina Brancato</name><name sortKey="Feiler, Christina E" sort="Feiler, Christina E" uniqKey="Feiler C" first="Christina E" last="Feiler">Christina E. Feiler</name><name sortKey="Grefen, Christopher" sort="Grefen, Christopher" uniqKey="Grefen C" first="Christopher" last="Grefen">Christopher Grefen</name><name sortKey="Gust, Andrea A" sort="Gust, Andrea A" uniqKey="Gust A" first="Andrea A" last="Gust">Andrea A. Gust</name><name sortKey="Hedrich, Rainer" sort="Hedrich, Rainer" uniqKey="Hedrich R" first="Rainer" last="Hedrich">Rainer Hedrich</name><name sortKey="Imkampe, Julia" sort="Imkampe, Julia" uniqKey="Imkampe J" first="Julia" last="Imkampe">Julia Imkampe</name><name sortKey="Krol, Elzbieta" sort="Krol, Elzbieta" uniqKey="Krol E" first="Elzbieta" last="Krol">Elzbieta Krol</name><name sortKey="Nurnberger, Thorsten" sort="Nurnberger, Thorsten" uniqKey="Nurnberger T" first="Thorsten" last="Nürnberger">Thorsten Nürnberger</name><name sortKey="Wallmeroth, Niklas" sort="Wallmeroth, Niklas" uniqKey="Wallmeroth N" first="Niklas" last="Wallmeroth">Niklas Wallmeroth</name></country><country name="Pays-Bas"><region name="Utrecht (province)"><name sortKey="Raaymakers, Tom M" sort="Raaymakers, Tom M" uniqKey="Raaymakers T" first="Tom M" last="Raaymakers">Tom M. Raaymakers</name></region><name sortKey="Oome, Stan" sort="Oome, Stan" uniqKey="Oome S" first="Stan" last="Oome">Stan Oome</name><name sortKey="Oome, Stan" sort="Oome, Stan" uniqKey="Oome S" first="Stan" last="Oome">Stan Oome</name><name sortKey="Van Den Ackerveken, Guido" sort="Van Den Ackerveken, Guido" uniqKey="Van Den Ackerveken G" first="Guido" last="Van Den Ackerveken">Guido Van Den Ackerveken</name><name sortKey="Van Den Ackerveken, Guido" sort="Van Den Ackerveken, Guido" uniqKey="Van Den Ackerveken G" first="Guido" last="Van Den Ackerveken">Guido Van Den Ackerveken</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Zhang, Heqiao" sort="Zhang, Heqiao" uniqKey="Zhang H" first="Heqiao" last="Zhang">Heqiao Zhang</name></noRegion><name sortKey="Chai, Jijie" sort="Chai, Jijie" uniqKey="Chai J" first="Jijie" last="Chai">Jijie Chai</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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